One of the most recognizable guitar intros ever written. Slash's tone on Appetite for Destruction is the textbook Les Paul through a cranked Marshall JCM800 sound: thick, warm humbuckers pushing a hot British amp into singing, vocal-like overdrive. The JCM800 is doing most of the work here, with its aggressive midrange and natural compression when pushed hard. A touch of reverb from the studio and Slash's fluid vibrato complete the picture.