The descending lead hook on Reptilia is Nick Valensi's Epiphone Riviera — a semi-hollow with bright P-94 single-coils — pushed by a Visual Sound Jekyll & Hyde overdrive into a loud, clean Fender Hot Rod DeVille. It's not high gain: the grind is edge-of-breakup amp headroom plus a light overdrive. Producer Gordon Raphael tracked the band at Transporterraum in NYC with a single Sennheiser MD 421 per amp straight into an API preamp, no EQ — and hard-panned the two interlocking guitars across the stereo field.
Hybrid picking isn't a country-only technique. Mark Knopfler, Albert Collins, and Scotty Moore built careers on it in rock and blues. Here's the technique, where it applies, and the specific moments where using your middle finger changes a phrase from good to right.
Jack White's tone settings explained: White Stripes Silvertone amp crunch, Seven Nation Army Big Muff fuzz, Whammy settings, and how to nail it on modern gear.
Exact settings for the Marshall JCM800 across blues, classic rock, hard rock, and metal, on the real amp and on Helix, Quad Cortex, and Katana models.