Plug In Baby features Matt Bellamy's signature combination of heavy fuzz and a DigiTech Whammy for the iconic riff. The Manson guitar runs through a fuzz pedal into a cranked Marshall for a thick, aggressive distortion, while the Whammy adds an octave-up effect that gives the riff its distinctive screaming, synth-like quality. The riff itself is a rapid-fire chromatic run that is instantly recognizable.